Merck
CN
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文件

安全信息

284327

Sigma-Aldrich

1,6-二硝基芘

98%

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经验公式（希尔记法）:
C16H8N2O4
CAS号:
42397-64-8
分子量:
292.25
MDL编号:
MFCD00010494
PubChem化学物质编号:
24857148

检测方案

98%

mp

>300 °C (lit.)

SMILES字符串

[O-][N+](=O)c1ccc2ccc3c(ccc4ccc1c2c34)[N+]([O-])=O

InChI

1S/C16H8N2O4/c19-17(20)13-8-4-10-2-6-12-14(18(21)22)7-3-9-1-5-11(13)16(10)15(9)12/h1-8H

InChI key

GUXACCKTQWVTLG-UHFFFAOYSA-N

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一般描述

1,6-Dinitropyrene is a potent mutagenic components of diesel exhaust and air pollutant. 1,6-Dinitropyrene is an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes.

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B E Butterworth et al.
Mutation research, 122(1), 73-80 (1983-10-01)
1,6-Dinitropyrene (DNP) was found to be an extremely potent genotoxicant in metabolically competent primary cultures of human and rat hepatocytes. Dose-dependent increases in DNA repair as measured by unscheduled DNA synthesis (UDS) were observed in the range from 0.05 to
H Ohgaki et al.
Cancer letters, 25(3), 239-245 (1985-01-01)
1-Nitropyrene (1-NP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP), which are potent mutagenic components of diesel exhaust and air pollutants, were injected subcutaneously into the back of F344 rats. No tumor was induced by experimental day 650 in rats treated with 40
B A Smith et al.
Mutation research, 379(1), 61-68 (1997-10-23)
Direct pulmonary instillation of 1,6-dinitropyrene (DNP) into male Fischer 344 rats results in a dose-dependent induction of lung tumors and 6-thioguanine-resistant (TGr) T-lymphocytes. The treatment also results in DNP binding to dG in the lung and in T-lymphocytes. In the
Akiko H Hashimoto et al.
Environmental and molecular mutagenesis, 47(4), 277-283 (2006-02-21)
1,6-Dinitropyrene (1,6-DNP) is a ubiquitous airborne pollutant found in diesel exhaust. In this study, mutagenesis was examined in the lungs of gpt-delta transgenic mice after intratracheal instillation of 0-0.1 mg 1,6-DNP. In addition, the 1,6-DNP-induced gpt mutation spectrum was compared
I B Lambert et al.
Mutation research, 484(1-2), 19-48 (2001-12-06)
We have characterized 202 lacI(-) mutations, and 158 dominant lacI(-d) mutations following treatment of Escherichia coli strains NR6112 and EE125 with 1-nitroso-6-nitropyrene (1,6-NONP), an activated metabolite of the carcinogen 1,6-dinitropyrene. In all, 91% of the induced point mutations occurred at
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