396494
氨基胍 盐酸盐
≥98%
别名:
甲脒肼 盐酸盐
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关于此项目
线性分子式:
NH2NHC(=NH)NH2 · HCl
化学文摘社编号:
分子量:
110.55
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
217-707-7
Beilstein/REAXYS Number:
3909606
MDL number:
Assay:
≥98%
Form:
solid
InChI key
UBDZFAGVPPMTIT-UHFFFAOYSA-N
InChI
1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
SMILES string
Cl.NNC(N)=N
assay
≥98%
form
solid
Quality Level
mp
162-166 °C (lit.)
functional group
amine, hydrazine
General description
在一项研究中已经报道了氨基胍盐酸盐可作为动物一氧化氮（NO）-合酶的抑制剂。已采用傅立叶和最小二乘法对盐酸氨基胍的晶体结构进行了研究。其晶体为单斜晶体，氨基胍离子的胍部分是平面结构。
Application
氨基胍盐酸盐可作为一氧化氮合酶（NOS）的抑制剂，用于研究其对大鼠结扎性牙周炎牙槽骨损失的影响。它可用于合成5-脒腙衍生物，其具有抗 大肠杆菌 和 金黄色葡萄球菌的抗菌活性。
Biochem/physiol Actions
构成型和诱导型一氧化氮合酶两者都抑制。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1B
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lina Nordquist et al.
Advances in experimental medicine and biology, 765, 185-193 (2012-08-11)
Sustained hyperglycemia is closely associated with increased risk to develop nephropathy. We have previously reported alterations in the intrarenal oxygen metabolism already after the early onset of diabetes. Furthermore, formation of advanced glycation end-products (AGE) is postulated as a major
The crystal structure of aminoguanidine hydrochloride.
Bryden JH.
Acta Crystallographica, 10(11), 677-680 (1957)
A K Gadad et al.
European journal of medicinal chemistry, 35(9), 853-857 (2000-09-28)
6-Arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamides 3 on Vilsmeier-Haak reaction produced 5-formyl-6-arylimidazo[2,1-b]-1,3, 4-thiadiazole-2-[N-(dimethylaminomethino)]sulfonamides 4, while 3 on treatment with potassium thiocyanate in the presence of bromine in acetic acid produced 5-thiocyanato-2-sulfonamides 6. Interaction of 4 with aminoguanidine hydrochloride in ethanol produced the corresponding 5-guanylhydrazone derivatives
A K Glyan'ko
Biochemistry. Biokhimiia, 78(5), 471-476 (2013-07-16)
The level of nitric oxide (NO) in roots of 2-day-old etiolated pea (Pisum sativum L.) seedlings was investigated by fluorescence microscopy using the fluorescent probe 4,5-diaminofluorescein diacetate. Segments representing transversal (cross) cuts of the roots having thickness of 100 to
Rekha Jagadish et al.
Journal of Indian Society of Periodontology, 18(1), 59-64 (2014-04-20)
Alveolar bone loss is the most striking feature of periodontal disease. The aim of this study was to investigate the effect of a cyclooxygenase (COX) pathway inhibitor and nitric oxide synthase (NOS) inhibitor in the reduction of alveolar bone loss
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