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371955-M

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

Name: H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
Brand: MM

A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.

别名:

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem, 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₇N₃O₂S · 2HCl

化学文摘社编号:

108930-17-2

分子量:

364.29

UNSPSC Code:

12352200

MDL number:

MFCD00036961

Assay:

≥98% (TLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, protect from light

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属性

assay

≥98% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

water: 20 mg/mL

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N3C(CNCC3)C)c1c2c(cncc2)ccc1.[Cl-].[Cl-].[H+].[H+]

InChI

1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H

InChI key

OARGPFMFRLLKPF-UHFFFAOYSA-N

说明

General description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 µM), protein kinase A (K_i = 3.0 µM), protein kinase C (K_i = 6 µM), and protein kinase G (K_i = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Primary Target
MLCK

Target K_i: 3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

Further dilute with aqueous buffers just prior to use.

Other Notes

Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res.54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap.263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res.203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun.187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res.525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther.255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys.Res. Commun.151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun.125, 258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c