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Merck
CN

C0869

南蛇藤醇

≥98% (HPLC), solid, antioxidant

别名:

10-羟基-2,4a,6a,9,12b,14a-六甲基-11-氧代-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14 b-十氢化-苉-2-羧酸, 雷公藤红素

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关于此项目

经验公式（希尔记法）:
C29H38O4
化学文摘社编号:
34157-83-0
分子量:
450.61
UNSPSC Code:
12352200
PubChem Substance ID:
329774823
NACRES:
NA.77
MDL number:
MFCD03424073

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产品名称

南蛇藤醇, ≥98% (HPLC), solid

SMILES string

CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O

InChI key

KQJSQWZMSAGSHN-JJWQIEBTSA-N

InChI

1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

assay

≥98% (HPLC)

form

solid

color

red

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

−20°C

Quality Level

100

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相关类别

Application

使用雷公藤红素：
  • 腹腔注射至试验小鼠研究其在非酒精性脂肪肝(NAFLD)中的作用
  • 用在培养基中研究其对人角朊细胞培养基中脂多糖诱导的炎症损伤的影响
  • 用于研究其在VCaP细胞体内和体外的作用

Biochem/physiol Actions

雷公藤红素是一种五嗪三萜烯,自然存在于雷公藤中。它对治疗类风湿性关节炎有效。雷公藤红素可阻止蛋白酶体和核因子Κb发挥作用。
雷公藤红素是一种强效抗氧化剂和抗炎剂。
雷公藤红素是一种强效抗氧化剂和抗炎剂。它是一种新的HSP90抑制剂（破坏Hsp90/Cdc37复合物），具有抗癌作用（抗血管生成-抑制血管内皮生长因子受体表达）；抗氧化剂（抑制脂质过氧化）和抗炎活性（抑制iNOS和炎性细胞因子的产生）。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000284082
0000284082
0000219458
0000220786
0000220786

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Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1
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Molecular Metabolism, 6(1), 138-147 (2017)
A C Allison et al.
Progress in neuro-psychopharmacology & biological psychiatry, 25(7), 1341-1357 (2001-08-22)
In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes
Radhamani Kannaiyan et al.
Cancer letters, 303(1), 9-20 (2010-12-21)
Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and
Mengfei Liu et al.
Nature communications, 12(1), 4560-4560 (2021-07-29)
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore the mechanistic role of super-enhancers linking cytokine TNFα with chemokine
Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells
Xiong Y, et al.
Biomedicine and Pharmacotherapy, 105, 798-804 (2018)
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