I8250
3-碘- L -酪氨酸
Tyrosine hydroxylase inhibitor
别名:
3-单碘- L -酪氨酸
产品名称
3-碘- L -酪氨酸,
杂质
~5% tyrosine
mp
210 °C (dec.) (lit.)
溶解性
dilute aqueous acid: soluble
储存温度
−20°C
SMILES字符串
N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
InChI
1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChI key
UQTZMGFTRHFAAM-ZETCQYMHSA-N
基因信息
human ... TH(7054)
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一般描述
与二碘酪氨酸偶联的碘酪氨酸可合成 3，5，3′-三碘甲状腺原氨酸 (T3) 或 3,3′,5′-三碘甲状腺原氨酸 (rT3)。
应用
3-碘-L-酪氨酸已作为酪氨酸羟化酶的抑制剂用于 果蝇 和蚕蛹。
生化/生理作用
3-碘酪氨酸 (3-IY) 抑制酪氨酸羟化酶，后者催化酪氨酸形成左旋多巴。严重甲减和甲状腺肿时，碘酪氨酸脱碘酶缺乏导致血清和尿中 3-IY 水平升高。
TH（酪氨酸 3-羟化酶）负责催化去甲肾上腺素能生物合成途径的第一步。TH 突变 与酪氨酸羟化酶缺乏相关，导致诸如婴儿型帕金森综合征和多巴（ 多巴胺 ）反应性肌张力障碍以及围产期发病的脑病。
酪氨酸羟化酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Jacqueline Studer et al.
Journal of forensic sciences, 59(6), 1650-1653 (2014-07-01)
Catecholamines, especially noradrenalin, are essential in the control of respiration and arousal. Thus, an impaired production of these neurotransmitters may contribute to the occurrence of sudden infant death syndrome (SIDS). The first step of the noradrenergic synthesis pathway is catalyzed
L G Harsing et al.
Neuroscience, 77(2), 419-429 (1997-03-01)
Striatal slices from the rat were preincubated with [3H]GABA and superfused in the presence of nipecotic acid and aminooxyacetic acid, inhibitors of high-affinity GABA transport and GABA aminotransferase, respectively. GABA efflux was estimated by monitoring tritium efflux, 98% of which
Anionic iodotyrosine residues are required for iodothyronine synthesis
De Vijlder JJ and den Hartog MT
European Journal of Endocrinology, 138(2), 227-231 (1998)
Mutations in the iodotyrosine deiodinase gene and hypothyroidism
Moreno J, et al.
The New England Journal of Medicine, 358(17), 1811-1818 (2008)
A new brain dopamine-deficient Drosophila and its pharmacological and genetic rescue
Cichewicz K, et al.
Genes, Brain, and Behavior, 16(3), 394-403 (2017)
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