M9020
美加明 盐酸盐
≥98% (TLC), powder, nAChR antagonist
别名:
2-（甲氨基）异樟烷 盐酸盐, N,2,3,3-四甲基二环 [2.2.1] 庚烷-2-胺 盐酸盐, 盐酸美加明
产品名称
美加明 盐酸盐,
表单
powder
质量水平
溶解性
ethanol: 122 mg/mL
H2O: 47 mg/mL
isopropanol: 476 mg/mL
glycerol: 95 mg/mL
创始人
AstraZeneca
SMILES字符串
Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
InChI
1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
InChI key
PKVZBNCYEICAQP-CIISUUNXSA-N
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相关类别
应用
在电流钳记录期间，美卡拉明盐酸盐已被用作细胞外盐水中的添加剂以减少突触输入。它还被用作主动脉体神经元和 MLO-Y4 细胞中的非选择性烟碱乙酰胆碱受体阻断剂。
生化/生理作用
非竞争性烟碱乙酰胆碱受体拮抗剂；优先阻断自主神经节的烟碱受体；穿过血脑屏障。
特点和优势
该化合物在受体分类和信号转导手册的乙酰胆碱受体（烟碱型）页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物由 AstraZeneca 公司开发。若要浏览其他制药公司研发的化合物和批准的药物/候选药物列表，请单击此处。
免责声明
溶液在高压灭菌时稳定。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies
Piskuric NA, et al.
Experimental Physiology, 99(1), 248-261 (2014)
M I Damaj et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1284-1291 (1999-11-24)
Pharmacological mechanisms involved in nicotine-induced seizures were investigated in mice by testing the ability of several nicotinic agonists in producing seizures after peripheral administration. In addition, nicotinic antagonists such as hexamethonium, mecamylamine, dihydro-beta-erythroidine, and methyllycaconitine citrate (MLA) were used in
P E Castillo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9180-9191 (1999-10-26)
The main olfactory bulb is a critical relay step between the olfactory epithelium and the olfactory cortex. A marked feature of the bulb is its massive innervation by cholinergic inputs from the basal forebrain. In this study, we addressed the
Acetylcholine affects osteocytic MLO-Y4 cells via acetylcholine receptors
Ma Y, et al.
Molecular and cellular endocrinology, 384(1-2), 155-164 (2014)
G Panagis et al.
Synapse (New York, N.Y.), 35(1), 15-25 (1999-12-01)
In the present study the neuronal expression of Fos, the protein product of c-fos, was used to study changes in neuronal activity in nerve terminal regions of the ascending dopaminergic system during nicotine withdrawal. Rats were infused for 14 days
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