S1250
(-)-α-散道宁
≥99%
别名:
(3 S ,5a S ,9b S )-3a,5,5a,9b-四氢-3,5a,9-三甲基萘 [1,2- b 呋喃-2,8 (3H,4 H ) 二酮, Semenen
方案
≥99%
mp
172-173 °C (lit.)
储存温度
2-8°C
SMILES字符串
C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(C)=C3[C@H]2OC1=O
InChI
1S/C15H18O3/c1-8-10-4-6-15(3)7-5-11(16)9(2)12(15)13(10)18-14(8)17/h5,7-8,10,13H,4,6H2,1-3H3/t8-,10-,13-,15-/m0/s1
InChI key
XJHDMGJURBVLLE-BOCCBSBMSA-N
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一般描述
(−)-α-山道年是(Santonin)一种倍半萜烯内酯。它存在于青蒿属植物中。
应用
(−)-α-山道年已被用作一种桉叶烷型倍半萜烯,用于研究其对231MFP乳腺癌细胞存活率下降的影响。
生化/生理作用
(−)-α-山道年具有抗蠕虫特性。它对肠道蛔虫有治疗作用。
警示用语:
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
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Cell Chemical Biology, 26(7), 1027-1035 (2019)
Chapter 3 - Natural Products
Sharma S and Anand N
Pharmacognosy Journal , 25(7), 71-123 (1997)
Fungal hydroxylation of (-)-alpha-santonin
Bustos D A
Report Intl Narcotics Control Brd 03, 2, 1-6 (2012)
Xing Chen et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 13(1), 353-362 (2011-11-29)
α-Santonin is the first organic compound observed to feature a photoinduced rearrangement and is now known to undergo a series of photochemical processes under UV irradiation. On the basis of the considerable interest of this system as a prototype, and
Francisco F P Arantes et al.
European journal of medicinal chemistry, 45(12), 6045-6051 (2010-10-26)
Ten novel α-santonin derivatives have been synthesized as cytotoxic agents. The in vitro antitumor activity of these compounds has been evaluated against cancer cells lines. Structure-activity relationships indicate that α-methylene-γ-lactone and endoperoxide functionalities play important roles in conferring cytotoxicity. The
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