Leveraging Traditional Chromatography Techniques for Downstream Purification of Novel Modalities

WEBINAR

Novel modalities such as adeno-associated virus (AAV), lentiviral vectors (LVV), and plasmid DNA (pDNA) are gaining prominence with clinical experience and commercialized treatments. A key barrier in bioprocessing of such complex molecules is in the downstream chromatography step where improving process recoveries and efficiencies remain top priorities. Could we leverage well-established, traditional chromatography steps using chemistries such as ion exchange (IEX) to de-bottleneck and streamline the purification of these newer therapies? Learn how to implement chromatographic techniques using resin or membrane formats in your viral vector or pDNA processes.

In this webinar, you will learn:

• Insights into AAV, LVV, and pDNA process flows and manufacturing challenges
• Compatibility of implementing IEX chromatography in downstream bioprocessing and alternatives to affinity chromatography
• Data-driven case studies on the performance of Natrix^®, Eshmuno^®, and Fractogel^® family of resins in downstream purification