Harvest preconcentration using single-pass tangential flow filtration (SPTFF) offers an effective solution to increase the productivity of the protein A capture step of monoclonal antibody purification processes. The benefits of SPTFF concentration for high-concentration streams are maximized when clarification steps are optimized for impurity clearance.
In this webinar, we will provide guidance and best practices for assessing different approaches to maximize the benefits of SPTFF concentration and improved productivity of an intensified protein A capture step.
In this webinar, you will learn:
- Harvest Concentration by SPTFF
- Impact of clarification on Harvest concentration
- Intensification of batch chromatography
Speaker
Akshat Gupta
Merck
Associate Director, Global BioPharma Center of Excellence
Akshat Gupta is the associate director of applications engineering, Global Biopharma Center of Excellence. Akshat has more than 10 years of experience in the biopharmaceutical industry, focused on process development and manufacturing sciences. His areas of specialization include cell culture clarification and tangential flow filtration. He holds an M.S. and a Ph.D. in chemical engineering from the University of Massachusetts, Lowell, where is also an adjunct faculty member in the chemical engineering department.
Pharma and biopharma manufacturing
- Pharma and biopharma manufacturing
Duration:1h
Language:English
Session 1:presented July 27, 2023
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