Home WebinarsProcess intensification using modified branched chain amino acids

Process intensification using modified branched chain amino acids

WEBINAR

Increasing demands for biotherapeutics require innovative solutions for process intensification. Highly concentrated cell culture media development is limited by low solubility of leucine and isoleucine. Highly soluble, bioavailable N-lactoyl-leucine and N-lactoyl-isoleucine sodium salts were developed for fed-batch and perfusion processes. They enabled the development of concentrated media applied to in-line dilution processes. Modified amino acids demonstrated comparable performance to canonical amino acids regarding cell growth, productivity, and product quality in CHO cells, enabling next-generation bioprocesses with reduced storage requirements and smaller production footprints.

In this webinar, you will learn:

How to concentrate your media & feeds by replacing low soluble amino acids with their modified version.
How to intensify your processes in either Fed-batch or Perfusion Applications.
How modified amino acids are metabolized by Chinese Hamster Overy cells.

Speaker List

Dr. Aline Zimmer

Merck

R&D Director

Aline Zimmer is currently R&D Director, responsible for the advanced cell culture technology department at our company. Aline and her team are responsible for the development of new chemicals for cell culture media used to produce recombinant therapeutical proteins or vaccines.

Aline holds an engineering degree in biochemistry and biotechnology from the National Institute of Applied Sciences (INSA) in Lyon, France, a master in cellular physiopathology from the University of Lyon and a PhD degree in immunology from the University of Paris. She worked in immunotherapy biomarker research at Stallergenes-Greer before joining our company in 2011.

Kalyn McDermott

Merck

Senior Strategic Product Manager

Kalyn McDermott is a Global Strategic Product Manager for upstream raw materials at our company, specializing in Poloxamer and amino acids for bioprocessing applications. With over five years of industry experience, she holds a bachelor's degree in Chemistry from Providence College and a Master of Science in Engineering, Science, and Technology Entrepreneurship from The University of Notre Dame.