From Raman to Real-Time Control - Unlocking Smarter Bioprocessing with a PAT Orchestration Platform

Webinar

Detailed description:

This webinar presents a practical use case of a PAT integration in a fed-batch cell culture process, using ProCellics™ Raman Analyzer and Siemens SIPAT orchestration platform. Ready-to-use chemometric models enabled real-time monitoring of Critical Process Parameters (CPPs) and Critical Quality Attributes (CQAs), including glucose, lactate, and protein titer. Raman predictions and offline reference measurements were integrated into a common interface, and a feedback control loop assessed a real-time glucose-based feeding strategy. The session covers the experimental setup, OPC UA^® connectivity, integration approach, key learnings, and future opportunities for PAT-enabled monitoring, control, and automation.

In this webinar, attendees will learn

• How Raman PAT sensors, chemometric models, Open Platform Communications United Architecture (OPC UA^®) connectivity, and centralized PAT orchestration enable scalable PAT implementations across bioprocessing workflows
• Opportunities to connect analytical workflows and integrate emerging technologies as digital manufacturing ecosystems continue to evolve