ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
Synonyms:
ABC39, ALDL1, ALDR, ALDRP, hALDR
Species:
Human ABCD2 (225), Mouse Abcd2 (26874), Rat Abcd2 (84356), sheep ABCD2 (101119199), naked mole-rat Abcd2 (101706287), domestic guinea pig Abcd2 (100715583), Zebrafish abcd2 (100537809), chicken ABCD2 (417694), dog ABCD2 (477643), cow ABCD2 (526436)
UniProtKB ID:
Gene ID:
- Human(225) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
- Mouse(26874) ATP-binding cassette, sub-family D (ALD), member 2
- Rat(84356) ATP-binding cassette, subfamily D (ALD), member 2
- sheep(101119199) ATP-binding cassette, sub-family D (ALD), member 2
- naked mole-rat(101706287) ATP-binding cassette, sub-family D (ALD), member 2
- domestic guinea pig(100715583) ATP-binding cassette, sub-family D (ALD), member 2
- Zebrafish(100537809) ATP-binding cassette, sub-family D (ALD), member 2
- chicken(417694) ATP-binding cassette, sub-family D (ALD), member 2
- dog(477643) ATP-binding cassette, sub-family D (ALD), member 2
- cow(526436) ATP-binding cassette, sub-family D (ALD), member 2
- domestic cat(101095424) ATP-binding cassette, sub-family D (ALD), member 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.