EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Synonyms:
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Species:
Human EIF2S1 (1965), Mouse Eif2s1 (13665), Rat Eif2s1 (54318), chicken EIF2S1 (423279), Goat EIF2S1 (100861133), domestic cat EIF2S1 (101091455), sheep EIF2S1 (101113414), domestic guinea pig Eif2s1 (100716377), cow EIF2S1 (327694), dog EIF2S1 (480361)
UniProtKB ID:
Gene ID:
- Human(1965) Summary: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]
- Mouse(13665) eukaryotic translation initiation factor 2, subunit 1 alpha
- Rat(54318) eukaryotic translation initiation factor 2, subunit 1 alpha
- chicken(423279) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- Goat(100861133) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- domestic cat(101091455) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- sheep(101113414) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- domestic guinea pig(100716377) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- cow(327694) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- dog(480361) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- naked mole-rat(101723170) eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-EIF2S1 (pSer51) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-EIF2S1 (pSer49) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-eIF-2α Antibody, clone 3M6 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
flow cytometry
immunocytochemistry
western blot
flow cytometry
immunocytochemistry
western blot
Monoclonal Anti-EIF2S1 (phospho S51) antibody produced in rabbit, clone IO-5,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-eIF2α antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
EIF2S1, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human