CN
PSENEN
presenilin enhancer gamma secretase subunit
Synonyms:
MSTP064, PEN-2, PEN2
Species:
Human PSENEN (55851), Mouse Psenen (66340), Rat Psenen (292788), Zebrafish psenen (402810), dog PSENEN (476479), sheep PSENEN (101120856), naked mole-rat Psenen (101700116), domestic guinea pig Psenen (100724086), cow PSENEN (493993), domestic cat PSENEN (101084076)
UniProtKB ID:
Gene ID:
- Human(55851) Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008]
- Mouse(66340) presenilin enhancer 2 homolog (C. elegans)
- Rat(292788) presenilin enhancer 2 homolog (C. elegans)
- Zebrafish(402810) presenilin enhancer 2 homolog
- dog(476479) presenilin enhancer 2 homolog (C. elegans)
- sheep(101120856) presenilin enhancer 2 homolog (C. elegans)
- naked mole-rat(101700116) presenilin enhancer 2 homolog (C. elegans)
- domestic guinea pig(100724086) presenilin enhancer 2 homolog (C. elegans)
- cow(493993) presenilin enhancer 2 homolog (C. elegans)
- domestic cat(101084076) presenilin enhancer 2 homolog (C. elegans)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PSENEN antibody produced in mouse, clone 1C12-G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-PSENEN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PEN2 (ab1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PEN2/PSENEN Antibody, clone 6J5O4, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Anti-Pen-2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot