CN
RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
Synonyms:
CRAF, NS5, Raf-1, c-Raf
Species:
Human RAF1 (5894), Mouse Raf1 (110157), Rat Raf1 (24703), Horse RAF1 (100051110), domestic guinea pig Raf1 (100720110), Domestic Rabbit RAF1 (100347407), sheep RAF1 (101103190), cow RAF1 (521196), naked mole-rat Raf1 (101721841), chicken RAF1 (396245) ...More
UniProtKB ID:
Gene ID:
- Human(5894) Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
- Mouse(110157) v-raf-leukemia viral oncogene 1
- Rat(24703) v-raf-leukemia viral oncogene 1
- Horse(100051110) v-raf-1 murine leukemia viral oncogene homolog 1
- domestic guinea pig(100720110) v-raf-1 murine leukemia viral oncogene homolog 1
- Domestic Rabbit(100347407) v-raf-1 murine leukemia viral oncogene homolog 1
- sheep(101103190) v-raf-1 murine leukemia viral oncogene homolog 1
- cow(521196) v-raf-1 murine leukemia viral oncogene homolog 1
- naked mole-rat(101721841) v-raf-1 murine leukemia viral oncogene homolog 1
- chicken(396245) v-raf-1 murine leukemia viral oncogene homolog 1
- dog(484648) v-raf-1 murine leukemia viral oncogene homolog 1
- domestic cat(101096047) v-raf-1 murine leukemia viral oncogene homolog 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-C-RAF, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-RAF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-RAF1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-phospho-C-RAF (pSer642) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Monoclonal Anti-RAF1 antibody produced in mouse, clone 4G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry
immunohistochemistry
western blot
flow cytometry
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
RAF1 (EE) (306-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Raf-1 RBD Protein, GST, 300 µg, GST fusion-protein, corresponding to the human Ras Binding Domain (RBD, residues 1-149) of Raf-1, expressed in E. coli. with purity 50% at full length molecular weight 42 kDa. For use in Affinity Binding Assays,
Species
human
Raf-1 Protein, Active, 10 µg, Active, N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D & Y341D, for use in Kinase Assays.,
Species
human