Merck
CN

SCN8A

sodium channel, voltage gated, type VIII, alpha subunit

Synonyms:
CERIII, CIAT, EIEE13, MED, NaCh6, Nav1.6, PN4
Species:
UniProtKB ID:
Gene ID:
  • Human(6334) Summary: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
  • Mouse(20273) sodium channel, voltage-gated, type VIII, alpha
  • Rat(29710) sodium channel, voltage gated, type VIII, alpha subunit
  • chicken(100857835) sodium channel, voltage gated, type VIII, alpha subunit
  • dog(477604) sodium channel, voltage gated, type VIII, alpha subunit
  • Horse(100052777) sodium channel, voltage gated, type VIII, alpha subunit
  • cow(537277) sodium channel, voltage gated, type VIII, alpha subunit
  • naked mole-rat(101711868) sodium channel, voltage gated, type VIII, alpha subunit
  • domestic guinea pig(100734003) sodium channel, voltage gated, type VIII, alpha subunit
  • sheep(101113744) sodium channel, voltage gated, type VIII, alpha subunit
  • domestic cat(101096578) sodium channel, voltage gated, type VIII, alpha subunit
  • chicken(426869) sodium channel, voltage gated, type VIII, alpha subunit

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SCN8A, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Monoclonal Anti-SCN8A antibody produced in mouse, clone 4G7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-SCN8A Sodium Channel Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-SCN8A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-SCN8A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Blocker

Product Number
Description
Species
Mexiletine hydrochloride, powder,
Species
human
Procaine hydrochloride, ≥97%,
Species
human
Mexiletine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Oxcarbazepine, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Scn8a,
Species
mouse