Merck
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TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

Synonyms:
CD258, HVEML, LIGHT, LTg, TR2
Species:
Human TNFSF14 (8740), Mouse Tnfsf14 (50930), Rat Tnfsf14 (301133), domestic guinea pig Tnfsf14 (100725147), dog TNFSF14 (611306), naked mole-rat Tnfsf14 (101725636), cow TNFSF14 (505521), domestic cat TNFSF14 (101096542)
UniProtKB ID:
O43557, A8K7M2, C9J5H4, O75476, Q6FHA1, Q8WVF8, Q96LD2
Gene ID:
  • Human(8740) Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(50930) tumor necrosis factor (ligand) superfamily, member 14
  • Rat(301133) tumor necrosis factor (ligand) superfamily, member 14
  • domestic guinea pig(100725147) tumor necrosis factor (ligand) superfamily, member 14
  • dog(611306) tumor necrosis factor (ligand) superfamily, member 14
  • naked mole-rat(101725636) tumor necrosis factor (ligand) superfamily, member 14
  • cow(505521) tumor necrosis factor (ligand) superfamily, member 14
  • domestic cat(101096542) tumor necrosis factor (ligand) superfamily, member 14

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ELISA

Product Number
Description
Species
RAB0496
Human LIGHT ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
AP1168
Anti-TNFSF14 Mouse mAb (4E3), liquid, clone 4E3, Calbiochem®,
Species Reactivity
human
Application
WH0008740M1
Monoclonal Anti-TNFSF14 antibody produced in mouse, clone 4E3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot

Proteins

Product Number
Description
Species
SRP3217
LIGHT from mouse, recombinant, expressed in E. coli, ≥96% (SDS-PAGE), ≥96% (HPLC), suitable for cell culture,
Species
mouse
SRP3106
LIGHT human, recombinant, expressed in Hi-5 Insect cells, ≥96% (SDS-PAGE), ≥96% (HPLC), suitable for cell culture,
Species
human

esiRNA

Product Number
Description
Species
EHU137531
MISSION® esiRNA, targeting human TNFSF14,
Species
human