CN
TOP2B
topoisomerase (DNA) II beta 180kDa
Synonyms:
TOPIIB, top2beta
Species:
Human TOP2B (7155), Mouse Top2b (21974), Rat Top2b (361100), Zebrafish top2b (569877), chicken TOP2B (395966), dog TOP2B (477044), domestic cat TOP2B (101088949), cow TOP2B (787256), cow TOP2B (282097), Domestic Rabbit TOP2B (100351427) ...More
UniProtKB ID:
Gene ID:
- Human(7155) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
- Mouse(21974) topoisomerase (DNA) II beta
- Rat(361100) topoisomerase (DNA) II beta
- Zebrafish(569877) topoisomerase (DNA) II beta
- chicken(395966) topoisomerase (DNA) II beta 180kDa
- dog(477044) topoisomerase (DNA) II beta 180kDa
- domestic cat(101088949) topoisomerase (DNA) II beta 180kDa
- cow(787256) topoisomerase (DNA) II beta 180kDa
- cow(282097) topoisomerase (DNA) II beta 180kDa
- Domestic Rabbit(100351427) topoisomerase (DNA) II beta 180kDa
- sheep(101103037) topoisomerase (DNA) II beta 180kDa
- domestic guinea pig(100714821) topoisomerase (DNA) II beta 180kDa
- naked mole-rat(101704972) topoisomerase (DNA) II beta 180kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TOP2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TOP2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TOP2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Etoposide for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human