UBE3B
ubiquitin protein ligase E3B
Synonyms:
BPIDS
Species:
Human UBE3B (89910), Mouse Ube3b (117146), Rat Ube3b (687633), Zebrafish ube3b (556864), Domestic Rabbit UBE3B (100338868), Horse UBE3B (100059725), domestic cat UBE3B (101085926), chicken UBE3B (374194), dog UBE3B (486311), domestic guinea pig Ube3b (100720918) ...More
UniProtKB ID:
Gene ID:
- Human(89910) Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
- Mouse(117146) ubiquitin protein ligase E3B
- Rat(687633) ubiquitin protein ligase E3B
- Zebrafish(556864) ubiquitin protein ligase E3B
- Domestic Rabbit(100338868) ubiquitin protein ligase E3B
- Horse(100059725) ubiquitin protein ligase E3B
- domestic cat(101085926) ubiquitin protein ligase E3B
- chicken(374194) ubiquitin protein ligase E3B
- dog(486311) ubiquitin protein ligase E3B
- domestic guinea pig(100720918) ubiquitin protein ligase E3B
- naked mole-rat(101709240) ubiquitin protein ligase E3B
- sheep(101123152) ubiquitin protein ligase E3B
- cow(512750) ubiquitin protein ligase E3B
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-UBE3B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-UBE3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry