146188
2-Hydroxy-5-methoxybenzoic acid
98%
Synonym(s):
5-Methoxysalicylic acid
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About This Item
Linear Formula:
CH3OC6H3(OH)CO2H
CAS Number:
Molecular Weight:
168.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-037-8
Beilstein/REAXYS Number:
2209647
MDL number:
Assay:
98%
Form:
powder
Quality Level
InChI key
IZZIWIAOVZOBLF-UHFFFAOYSA-N
InChI
1S/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11)
SMILES string
COc1ccc(O)c(c1)C(O)=O
assay
98%
form
powder
mp
141-143 °C (lit.)
functional group
carboxylic acid
Related Categories
General description
2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Application
2-Hydroxy-5-methoxybenzoic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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T Nishihata et al.
Journal of pharmacobio-dynamics, 7(5), 278-285 (1984-05-01)
The rectal absorption of pepleomycin sulfate (PEPS) in rats was increased significantly by the coadministration with each of diclofenac (DC), sodium 5-methoxysalicylate (5-MSA) and phenylalanine enamine of ethylacetoacetate (Enamine). 5-MSA increased the lymphatic uptake of PEPS after rectal administration while
Cole Emanuelson et al.
SLAS discovery : advancing life sciences R & D, 26(1), 58-66 (2020-09-30)
High-throughput matrix-assisted laser desorption/ionization mass spectrometry (HT-MALDI-MS) has garnered considerable attention within the drug discovery industry as an information-rich alternative to assays using light-based detection methods. To date, these efforts have been primarily focused on assays using protein or peptide
Maximilianos Kotsias et al.
PloS one, 14(1), e0210759-e0210759 (2019-01-18)
Protein O-glycosylation has shown to be critical for a wide range of biological processes, resulting in an increased interest in studying the alterations in O-glycosylation patterns of biological samples as disease biomarkers as well as for patient stratification and personalized
Kathrin Stavenhagen et al.
Molecular & cellular proteomics : MCP, 17(6), 1225-1238 (2017-12-14)
Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of the contact activation pathway as well as the classical and lectin complement pathways. It is known to be a highly glycosylated plasma glycoprotein. However, both the structural
Stephanie Holst et al.
Scientific reports, 7(1), 16623-16623 (2017-12-02)
To characterise pancreatic cancer cells from different sources which are used as model systems to study the metastatic behaviour in pancreatic ductal adenocarcinoma (PDAC), we compared the N-glycan imprint of four PDAC cells which were previously shown to differ in
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