Skip to Content
Merck
CN

164011

Methyl 3-chloro-3-oxopropionate

97%

Synonym(s):

Methyl malonyl chloride, Methyl chloroformylacetate

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
CH3OCOCH2COCl
CAS Number:
37517-81-0
Molecular Weight:
136.53
Beilstein:
1754078
EC Number:
253-540-6
MDL number:
MFCD00013657
UNSPSC Code:
12352100
PubChem Substance ID:
24850046
NACRES:
NA.22

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

Assay

97%

refractive index

n20/D 1.432 (lit.)

bp

57-59 °C/12 mmHg (lit.)

density

1.273 g/mL at 25 °C (lit.)

functional group

acyl chloride
ester

storage temp.

2-8°C

SMILES string

COC(=O)CC(Cl)=O

InChI

1S/C4H5ClO3/c1-8-4(7)2-3(5)6/h2H2,1H3

InChI key

UTBCRHAMJFMIIR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.

Application

Methyl 3-chloro-3-oxopropionate was used as a reagent in the synthesis of resin-bound 4-tosyl quinolinone, 1-anthracen-9-ylmethyl 3-methyl 2,2-dimethylmalonate and 1-(4-(3,5-dihydropyren-1-yl)butyl)-3-methyl 2,2-dimethylmalonate.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

176.0 °F - closed cup

Flash Point(C)

80 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCH9445
BCCC0301
BCBJ3603V
1425257V
MKBK0138V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A general solid phase synthesis of 4-substituted quinolinones via Pd-catalyzed cross coupling.
Xu C, et al.
Tetrahedron Letters, 47(28), 4885-4888 (3006)
Katharina C Kress et al.
Beilstein journal of organic chemistry, 8, 371-378 (2012-04-18)
4-Cyano-1,1'-biphenyl derivatives bearing ω-hydroxyalkyl substituents were reacted with methyl 3-chloro-3-oxopropionate or cyanoacetic acid, giving liquid-crystalline linear malonates and cyanoacetates. These compounds formed monotropic nematic phases at 62 °C down to ambient temperature upon cooling from the isotropic liquid. The mesomorphic
Solvent-free microwave-assisted Bingel reaction in carbon nanohorns.
Economopoulos SP, et al.
Journal of Materials Chemistry, 19(39), 7326-7331 (2009)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service