371130
1,4-Diisocyanatobutane
97.0%
Synonym(s):
Tetramethylene diisocyanate
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About This Item
Linear Formula:
OCN(CH2)4NCO
CAS Number:
Molecular Weight:
140.14
UNSPSC Code:
12162002
NACRES:
NA.23
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1756894
Quality Level
assay
97.0%
form
liquid
bp
102-104 °C/14 mmHg (lit.)
density
1.105 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
O=C=NCCCCN=C=O
InChI
1S/C6H8N2O2/c9-5-7-3-1-2-4-8-6-10/h1-4H2
InChI key
OVBFMUAFNIIQAL-UHFFFAOYSA-N
General description
1,4-Diisocyanatobutane is a highly reactive compound with two isocyanate (-NCO) groups separated by a butane chain. It can undergo reactions such as urethane formation, crosslinking, and chain extension. It is widely used as a building block to synthesize polyurethane-based materials with excellent flexibility, impact resistance, and mechanical properties, making them useful in tissue engineering, contact lenses, biocompatible coatings, adhesives, foams, elastomers, and sealants.
Application
1,4-Diisocyanatobutanecan be used in the following fields:
Tissue engineering -As a precursor to synthesize polyurethane composites which can be used as 3D scaffolds for tissue engineering,
Contact lenses- As a cross-linking agent to prepare inorganic-organic hydrogel contact lenses for high refractive index ocular refractive correction biomaterial,
Controlled drug delivery- As a chain extender to synthesize segmented polyurethanes for redox-sensitive controlled drug release systems.
Tissue engineering -As a precursor to synthesize polyurethane composites which can be used as 3D scaffolds for tissue engineering,
Contact lenses- As a cross-linking agent to prepare inorganic-organic hydrogel contact lenses for high refractive index ocular refractive correction biomaterial,
Controlled drug delivery- As a chain extender to synthesize segmented polyurethanes for redox-sensitive controlled drug release systems.
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Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
222.8 °F - closed cup
flash_point_c
106 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Polymerizable-group capped ZnS nanoparticle for high refractive index inorganic-organic hydrogel contact lens
Peili Zhao, et al.
Materials Science and Engineering, C, 90, 485-493 (2018)
Synthesis and characterization of redox-sensitive polyurethanes based on l-glutathione oxidized and poly(ether ester) triblock copolymers
Fabio S. Palumbo, et al.
Reactive and Functional Polymers, 126, 104986-104986 (2021)
3D-composite scaffolds from radiation-induced chitosan grafted poly(3-hydroxybutyrate) polyurethane
Maykel Gonzalez Torres
Materials Today Communications, 23, 100902-100902 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 371130-5G | 04061831833836 |
| 371130-1G | 04061831833829 |