392723
(DHQ)2PHAL
≥95%
别名:
氢化奎宁 1,4-(2,3-二氮杂萘)二醚
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关于此项目
经验公式（希尔记法）:
C48H54N6O4
化学文摘社编号:
分子量:
778.98
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5475677
Quality Segment
assay
≥95%
optical activity
[α]22/D +336°, c = 1.2 in methanol
mp
178 °C (dec.) (lit.)
SMILES string
CC[C@@H]1CN2CCC1CC2[C@H](Oc3nnc(O[C@@H](C4CC5CCN4C[C@@H]5CC)c6ccnc7ccc(OC)cc67)c8ccccc38)c9ccnc%10ccc(OC)cc9%10
InChI
1S/C48H54N6O4/c1-5-29-27-53-21-17-31(29)23-43(53)45(35-15-19-49-41-13-11-33(55-3)25-39(35)41)57-47-37-9-7-8-10-38(37)48(52-51-47)58-46(44-24-32-18-22-54(44)28-30(32)6-2)36-16-20-50-42-14-12-34(56-4)26-40(36)42/h7-16,19-20,25-26,29-32,43-46H,5-6,17-18,21-24,27-28H2,1-4H3/t29-,30+,31-,32+,43-,44-,45-,46-/m1/s1
InChI key
YUCBLVFHJWOYDN-PPIALRKJSA-N
General description
DHQ)2PHAL is a modified cinchona alkaloid.
Application
(DHQ)2PHAL may be used in the following processes:
- As a catalyst Asymmetric and chemoselective N-allylic alkylation of indoles with Morita-Baylis-Hillman carbonates to form pyrrolo[1,2-a]indole and pyrrolo[3,2,1-ij]quinoline derivatives.
- As a ligand for the osmium catalyzed-Sharpless asymmetric dihydroxylation step of (S)-a-benzoyloxy carboxylic acids multistep synthesis.
- As a ligand for the carbamate based asymmetric aminohydroxylation of styrene derivatives to form N-carbamate protected R-arylglycinols.
Sharpless 不对称双羟基化的配体，用于由 (E,E)- 或 (E,Z)-1,3-二烯酸甲酯不对称制备 syn-3,5-羟基羧酸酯。
Physical form
具有三取代 C=C 键的不饱和酯的不对称双羟基化。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)