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Merck
CN

525553

4-Phenyl-1-(2H)-phthalazinone

97%

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About This Item

Empirical Formula (Hill Notation):
C14H10N2O
CAS Number:
Molecular Weight:
222.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
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Product Name

4-Phenyl-1-(2H)-phthalazinone, 97%

InChI

1S/C14H10N2O/c17-14-12-9-5-4-8-11(12)13(15-16-14)10-6-2-1-3-7-10/h1-9H,(H,16,17)

SMILES string

O=C1NN=C(c2ccccc2)c3ccccc13

InChI key

XCJLBNVENUPHEA-UHFFFAOYSA-N

assay

97%

mp

240-244 °C (lit.)

functional group

phenyl

Quality Level

Application

4-Phenyl-1-(2H)-phthalazinone may be used in the synthesis of 2-chloro-N-(unsubstituted/substitutedphenyl) acetamide.

General description

4-Phenyl-1-(2H)-phthalazinone can be prepared from hydrazine sulphate and sodium hydroxide.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Wagdy M Eldehna et al.
European journal of medicinal chemistry, 89, 549-560 (2014-12-03)
A novel series of N-substituted-4-phenylphthalazin-1-ones 14a-g bearing different anilines at the N-2 of phthalazin-1-one scaffold via acetyl-flexible linker was designed and synthesized for the development of potential anticancer agents. Compounds 19a-g were synthesized by insertion of methylene (CH2) bridge at
Kazuko Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1326-1333 (2014-06-11)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and

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