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546062

Sigma-Aldrich

Rhodamine 19 perchlorate

Dye content ~95 %

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Synonym(s):
2-(6-Ethylamino-3-ethylimino-2,7-dimethyl-3H-xanthen-9-yl)-benzoic acid perchlorate, Rhodamine 575
Empirical Formula (Hill Notation):
C26H26N2O3 · HClO4
CAS Number:
62669-66-3
Molecular Weight:
514.95
EC Number:
263-686-2
MDL number:
MFCD00050850
PubChem Substance ID:
329758041
NACRES:
NA.47

form

crystalline

Quality Level

100

composition

Dye content, ~95%

mp

>300 °C (lit.)

λmax

>517 nm

fluorescence

λem 544 nm in ethanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OCl(=O)(=O)=O.CCNc1cc2OC3=CC(=N/CC)\C(C)=CC3=C(c2cc1C)c4ccccc4C(O)=O

InChI

1S/C26H26N2O3.ClHO4/c1-5-27-21-13-23-19(11-15(21)3)25(17-9-7-8-10-18(17)26(29)30)20-12-16(4)22(28-6-2)14-24(20)31-23;2-1(3,4)5/h7-14,27H,5-6H2,1-4H3,(H,29,30);(H,2,3,4,5)/b28-22+;

InChI key

WRJTXSZPMAXPRF-GVWDPOEBSA-N

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General description

Rhodamine 19 perchlorate is a molecule with high molar extinction coefficient (2 X 105 M-1 cm-1).

Application

Rhodamine 19 perchlorate has been used as a test molecule to identify small molecule inhibitors of the PDGFR (platelet-derived growth factor receptor β)/ERK (extracellular signal-regulated kinase) pathway using gene expression-based high-throughput screening.

Features and Benefits

Laser dye

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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J A H Inkster et al.
MedChemComm, 8(10), 1891-1896 (2017-12-26)
New chemical and radiochemical syntheses are described for the preparation of [
Efficiency enhancement in dye sensitized solar cells through co-sensitization of TiO2 nanocrystalline electrodes.
Saxena V, et al.
Applied Physics Letters, 100, 81-81 (2012)
Steven Daly et al.
Journal of the American Society for Mass Spectrometry, 28(1), 38-49 (2016-08-11)
Mass spectrometry is an extremely powerful technique for analysis of biological molecules, in particular proteins. One aspect that has been contentious is how much native solution-phase structure is preserved upon transposition to the gas phase by soft ionization methods such
Alena A Antipova et al.
Genome biology, 9(3), R47-R47 (2008-03-04)
Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability

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