745723
3-Methyl-1-butyne
95%
Synonym(s):
1-Isopentyne, 2-Methyl-3-butyne, 3,3-Dimethyl-1-propyne, Isopropylacetylene, Isopropylethyne
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About This Item
Empirical Formula (Hill Notation):
C5H8
CAS Number:
Molecular Weight:
68.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
209-925-6
MDL number:
Assay:
95%
Form:
liquid
InChI key
USCSRAJGJYMJFZ-UHFFFAOYSA-N
InChI
1S/C5H8/c1-4-5(2)3/h1,5H,2-3H3
SMILES string
C#CC(C)C
assay
95%
form
liquid
refractive index
n20/D 1.374
density
0.666 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
Related Categories
Application
3-Methyl-1-butyne can be used as a reactant in the ruthenium-catalyzed synthesis of functionalized cycloheptadienes and titanium-catalyzed [2+2+1] multicomponent pyrrole synthesis. It is also used as a precursor in the total syntheses of (+)-frondosin A, (−)-citrinadin A, (+)-citrinadin B and coraxeniolide A.
3-Methyl-1-butyne is a terminal alkyne that can be used to prepare:
- Maleimide-fused cyclopentenones by reacting with N-substituted maleimides via Co2(CO)8-mediated Pauson−Khand reaction.
- An alkyne carboxylic acid (Alkyne Segment C) intermediate, which is used in the total synthesis of oscillatoxin D and its analogs.
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Metal carbene-promoted sequential transformations for the enantioselective synthesis of highly functionalized cycloheptadienes.
Deng L, et al.
Journal of the American Chemical Society, 127(5), 1342-1343 (2005)
An unconventional approach to the enantioselective synthesis of caryophylloids.
Larionov, Oleg V and Corey, EJ
Journal of the American Chemical Society, 130(10), 2954-2955 (2008)
An enantioselective total synthesis and stereochemical revision of (+)-citrinadin B.
Kong K, et al.
Journal of the American Chemical Society, 135(30), 10890-10893 (2013)
Enantioselective total synthesis of (-)-citrinadin A and revision of its stereochemical structure.
Bian, Zhiguo and Marvin, Christopher C and Martin, Stephen F
Journal of the American Chemical Society, 135(30), 10886-10889 (2013)
Trimethylsilyl-Protected Alkynes as Selective Cross-Coupling Partners in Titanium-Catalyzed [2+ 2+ 1] Pyrrole Synthesis.
Chiu, Hsin-Chun and Tonks, Ian A
Angewandte Chemie (International Edition in English), 57(21), 6090-6094 (2018)
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