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805149

Sigma-Aldrich

PLGA nanoparticles

500 nm average diameter

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Synonym(s):
Degradex® PLGA, poly(D,L-lactide-co-glycolide)
Linear Formula:
(C3H4O2)x(C2H2O2)y
NACRES:
NA.23

form

powder

Quality Level

average diameter

500 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

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General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.

Application

Plain PLGA particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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705578-5MG-PW

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MMYOMAG-74K-13

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Articles

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Polymeric antioxidants are promising and effective new-generation antioxidant therapies. With flexibility of form as well as prolonged stability and circulation, these nanobiomaterials have superior bioavailability for drug delivery and antioxidant potential.

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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