911240
Poly(ethylene glycol) linear dendron
carboxyl terminated, PEG Mn 10,000, generation 4
Synonym(s):
Polyethylene glycol
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About This Item
Empirical Formula (Hill Notation):
C594H1096O321
Molecular Weight:
13374.87
UNSPSC Code:
51171641
NACRES:
NA.21
form
solid
mol wt
PEG Mn 10,000
generation 4
no. Surface Groups
16
color
white to off-white
storage temp.
−20°C
Related Categories
General description
- Polymer architecture: PEG-linear dendron
- Generation: 4
- PEG average Mn: 10,000
- End Group Functionality: Carboxylic acid
- No. Surface Groups: 16
- Calculated Mol. Wt.: 13374.98 g/mol
- Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible, biodegradable, and suitable for biomedical applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, enabling use for advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
Articles
Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.
Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).
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