913650
Polyoxyethylene bis(azide) solution
average Mn 450, 0.1 g/mL in THF
Synonym(s):
O,O′-Bis(2-azidoethyl)polyethylene glycol, PEG-diazide
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About This Item
Linear Formula:
N3(C2H4O)nC2H4N3
NACRES:
NA.23
UNSPSC Code:
12352125
Product Name
Polyoxyethylene bis(azide) solution, average Mn 450, 0.1 g/mL in THF
form
liquid
mol wt
PEG ~400 Da
average Mn 450
concentration
0.1 g/mL in THF
color
pale yellow
storage temp.
2-8°C
Quality Level
Related Categories
Application
PEG for cross-linking and used in "click" chemistry reactions. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. Polymer for preparing enzyme conjugates soluble in organic solvents; promising drug carrier.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system, Respiratory system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
0.5 °F
flash_point_c
-17.5 °C
Regulatory Information
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Biomaterials, 30(8), 1453-1461 (2008-12-23)
In this study, biodegradable PEG-peptide hydrogels have been synthesized using Click chemistry. A series of Arg-Gly-Asp (RGD) containing peptides were prepared via a solid phase synthesis approach, which were further functionalized with azide to yield peptide azide or peptide diazide.
Tilman Läppchen et al.
European journal of medicinal chemistry, 89, 279-295 (2014-12-03)
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