925047
KB02-COOH
Synonym(s):
2-((1-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetic acid, Functionalized scout fragment
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About This Item
Empirical Formula (Hill Notation):
C13H14ClNO4
CAS Number:
Molecular Weight:
283.71
MDL number:
NACRES:
NA.22
UNSPSC Code:
12352200
Application
KB02-COOH is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).
Related useful products may include cysteine fragment KB02 (912131), KB02-SLF (914738), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).
Technology spotlight: Proteomic Ligandability Assessment
Related useful products may include cysteine fragment KB02 (912131), KB02-SLF (914738), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).
Technology spotlight: Proteomic Ligandability Assessment
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Xiaoyu Zhang et al.
Nature chemical biology, 15(7), 737-746 (2019-06-19)
Ligand-dependent protein degradation has emerged as a compelling strategy to pharmacologically control the protein content of cells. So far, however, only a limited number of E3 ligases have been found to support this process. Here, we use a chemical proteomic
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