927457
SDASO-S crosslinker
≥95%
Synonym(s):
2,5-Dioxopyrrolidin-1-yl 3-((2-(3-methyl-3H-diazirin-3-yl)ethyl)sulfinyl)propanoate, Succinimidyl diazirine sulfoxide
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About This Item
Empirical Formula (Hill Notation):
C11H15N3O5S
Molecular Weight:
301.32
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.21
InChI
1S/C11H15N3O5S/c1-11(12-13-11)5-7-20(18)6-4-10(17)19-14-8(15)2-3-9(14)16/h2-7H2,1H3
InChI key
MSHAOLYSQMKWAS-UHFFFAOYSA-N
SMILES string
O=C(CCS(CCC1(N=N1)C)=O)ON2C(CCC2=O)=O
assay
≥95%
form
powder
mp
87 °C
storage temp.
−20°C
Quality Level
Application
SDASO-S (succinimidyl diazirine sulfoxide) is mass-spectrometry cleavable heterobifunctional cross-linker, which can be used in the analysis of protein structure, or protein-protein interactions. SDASO-S is photoactivated, allowing for the first time photocross-linking of proteins, and rapid, accurate analysis by MS.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Other Notes
https://www.sciencedirect.com/science/article/pii/S1535947621000578">Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Craig Gutierrez et al.
Molecular & cellular proteomics : MCP, 20, 100084-100084 (2021-04-30)
Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein-protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions nontargetable by specific chemistries remain difficult. Photochemistry has shown great
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