933651
Poly(caprolactone fumarate)
average Mn 5,000
Synonym(s):
PCLF, Polycaprolactone fumarate
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About This Item
Linear Formula:
C16H30O7(C20H30O9)n
NACRES:
NA.21
UNSPSC Code:
12352207
Product Name
Poly(caprolactone fumarate), average Mn 5,000
form
viscous liquid
mol wt
average Mn 5,000
color
clear, colorless
storage temp.
−20°C
Quality Level
Related Categories
Application
- Tissue engineering including bone and nerve regeneration
- 3D bioprinting
- Drug delivery
Poly(caprolactone fumarate) (PCLF) is a macromonomer consisting of poly(caprolactone) and fumarate repeating units. The bio-compatible poly(capralactone) units shows flexibility and fumarate repeat units provide cross linking ability without adding any toxic cross-linkers
Features and Benefits
- Biocompatible
- Crosslinkable via photopolymerization, radical polymerziation, thermal polymereization
- Flexible polymer chain
- Biodegradable via hydrolysis of the ster bonds in both PCL and fumarate segments
General description
Poly(caprolactone fumarate) (PCLF) is a crosslinkable, biodegradable polymer consisting of poly(caprolactone) (PCL) and unsaturated fumarate repeating units. This derivative of PCL can be crosslinked to form a three-dimensional polymer network or scaffold. PCLF has been widely investigated for tissue engineering, 3D bioprinting, and drug delivery applications due to its biodegradability, biocompatibility and mechanical performance.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Synthesis, Material Properties, and Biocompatibility of a Novel Self-Cross-Linkable Poly(caprolactone fumarate) as an Injectable Tissue Engineering Scaffold
Esmaiel J. et al.
Biomacromolecules, 6, 2503-2511 (2005)
Synthesis and manufacture of photocrosslinkable poly(caprolactone)-based three-dimensional scaffolds for tissue engineering applications
N. Castro et al.
Advances in Bioscience and Biotechnology, 2, 167-173 (2011)
M Brett Runge et al.
Acta biomaterialia, 8(1), 133-143 (2011-09-14)
Polycaprolactone fumarate (PCLF) is a cross-linkable derivative of polycaprolactone diol that has been shown to be an effective nerve conduit material that supports regeneration across segmental nerve defects and has warranted future clinical trials. Degradation of PCLF (PCLF(DEG)) releases toxic
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