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Merck
CN

936413

Fmoc-Val-Cit-OH

≥95%

Synonym(s):

(S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-5-ureidopentanoicacid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-L-ornithine (ACI), L-Ornithine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-, L-Ornithine, N5-(aminocarbonyl)-N2-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl]- (ZCI)

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About This Item

Empirical Formula (Hill Notation):
C26H32N4O6
CAS Number:
159858-21-6
Molecular Weight:
496.56
MDL number:
MFCD28139060
UNSPSC Code:
12352209
NACRES:
NA.22

Key Documents

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Quality Level

100

Assay

≥95%

form

powder or crystals

color

white to beige

storage temp.

2-8°C

SMILES string

C(OC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)C(C)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

InChI

InChI=1S/C26H32N4O6/c1-15(2)22(23(31)29-21(24(32)33)12-7-13-28-25(27)34)30-26(35)36-14-20-18-10-5-3-8-16(18)17-9-4-6-11-19(17)20/h3-6,8-11,15,20-22H,7,12-14H2,1-2H3,(H,29,31)(H,30,35)(H,32,33)(H3,27,28,34)/t21-,22-/m0/s1

InChI key

ZJLNQOIFTYLCHC-VXKWHMMOSA-N

Application

This is a cathepsin cleavable linker used in bioconjugation, specifically in the construction of antibody drug conjugates (ADC & Bioconjugation).

Features and Benefits

Fmoc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B.

Other Notes

ADC & Bioconjugation

Chemical Biology Tools

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000303193
0000303193
0000286105
0000286105

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Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies
Lai Q, et al.
European Journal of Medicinal Chemistry, 199, 112364-112364 (2020)
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Ye Z, et al.
International journal of nanomedicine, 26, 2443-2459 (2021)

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