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Merck
CN

936472

(S,R,S)-AHPC-pentanoic-acid

≥95%

别名:

6-[[(1S)-1-[[(2S,4R)-4-Hydroxy-2-[[[4-(4-methylthiazol-5-yl)phenyl]methyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-2,2-dimethylpropyl]amino]-6-oxohexanoic acid, 6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-6-oxohexanoic acid, L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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关于此项目

经验公式(希尔记法):
C28H38N4O6S
化学文摘社编号:
分子量:
558.69
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
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ligand

VH032

Quality Segment

assay

≥95%

form

powder

color

white to light yellow

storage temp.

2-8°C

SMILES string

C([C@@H](NC(CCCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

InChI

1S/C28H38N4O6S/c1-17-24(39-16-30-17)19-11-9-18(10-12-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)7-5-6-8-23(35)36/h9-12,16,20-21,25,33H,5-8,13-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1

InChI key

DKSZOQIYZOVHOL-TYBLODHISA-N

Application

(S, R, S)-AHPC-pentanoic-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Legal Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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