937754
Poly(D,L-lactic-co-glycolic acid)-block-poly(glutamic acid)
PLGA average Mn 25,000, mol wt (PGlu average Mn 5,000), lactide:glycolide 50:50
Synonym(s):
Amphiphilic, Block polymer, Drug delivery, Glutamic acid, PLGA, PLGA-b-PGlu, Poly(glutamic acid), Polyaminoacids
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About This Item
Linear Formula:
[(C3H4O2)a(C2H2O2)b]n O[C5H7NO3]m
NACRES:
NA.21
UNSPSC Code:
12162002
feed ratio
lactide:glycolide 50:50
mol wt
PLGA average Mn 25,000, (PGlu average Mn 5,000)
color
white to beige, powder
storage temp.
−20°C
Quality Level
Application
This polymer is a amphiphilic diblock copolymer composed of a hydrophobic PLGA block and a hydrophilic poly(glutamic acid) block. PLGA is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. Poly(glutamic acid) is biodegradable, non-toxic and non-immunogenic macromolecules. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, for drug delivery applications
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 88(1), 158-164 (2011-07-19)
Nanoparticles (NPs) with ternary components of polyethyleneimine (PEI), poly-(γ-glutamic acid) (γ-PGA), and poly(lactide-co-glycolide) (PLGA) were applied to carry and release saquinavir (SQV). Hydrophobic SQV was encapsulated in the particle core composed of PLGA to form SQV-PLGA NPs, and the surface
Ibrahim R Khalil et al.
International journal of molecular sciences, 18(2) (2017-02-06)
In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally
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