Skip to Content
Merck
CN

937819

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average Mn 2000, PLLA average Mn 5000

Synonym(s):

Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL5k, mPEGNH2-PLL

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
C3H9NO(OC2H4)x-(C6H13N2OBr)n
UNSPSC Code:
12162002
NACRES:
NA.21

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide, PEG average Mn 2000, PLLA average Mn 5000

InChI

1S/C11H25N3O3.BrH/c1-16-8-9-17-7-6-14-11(15)10(13)4-2-3-5-12;/h10H,2-9,12-13H2,1H3,(H,14,15);1H

SMILES string

COCCOCCNC(C(CCCC[NH3+])N[H])=O.[Br-]

form

chunks

mol wt

PEG average Mn 2000
PLLA average Mn 5000

color

white

storage temp.

2-8°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Application

*Non-viral gene delivery application
*Targeted drug delivery application
*Protein coatings and tissue culture

Features and Benefits

*Self-assemble capability to form micelles and polymersomes
*Amine functional group at the side chain enables further rapid functionalization
*Cationic poly(L-lysine) has excellent DNA and RNA condensation property
*Biodegradable, biocompatible and water soluble

General description

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications. The cationic PLL block can bind to DNA or RNA, as well as other therapuetic agents, while the amine-functionalized PEG block can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCV7378

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Karlsson J, et al.
Expert Opinion on Drug Delivery, 17, 1395-1410 (2020)
Poly (??amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
Iqbal S, et al.
European Polymer Journal, 141, 110097-110097 (2020)
Qi Y Wang et al.
Journal of materials chemistry. B, 7(7), 1076-1086 (2019-02-21)
Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service