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Merck
CN

938300

Monobromomaleimide-BCN

≥95%

Synonym(s):

((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-(2-(3-bromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamido)ethoxy)ethoxy)ethyl)carbamate

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About This Item

Empirical Formula (Hill Notation):
C23H30BrN3O7
CAS Number:
Molecular Weight:
540.40
NACRES:
NA.21
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InChI

1S/C23H30BrN3O7/c24-19-13-21(29)27(22(19)30)14-20(28)25-7-9-32-11-12-33-10-8-26-23(31)34-15-18-16-5-3-1-2-4-6-17(16)18/h13,16-18H,3-12,14-15H2,(H,25,28)(H,26,31)/t16-,17+,18-

InChI key

PWCDDJDQWZOLIE-BCDXTJNWSA-N

SMILES string

[H][C@]1([C@H]2COC(N([H])CCOCCOCCN([H])C(CN3C(C=C(Br)C3=O)=O)=O)=O)[C@]2([H])CCC#CCC1

assay

≥95%

form

paste (Liquid or Semi-Solid or Solid)

color

colorless to light yellow

storage temp.

−20°C

Quality Level

Application

New reagent for cysteine modification, useful for ADC & Bioconjugation.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers
Wall A, et al.
Organic & Biomolecular Chemistry, 17(34), 7870-7873 (2019)
Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly
Dinesen A, et al.
Bioconjugate Chemistry, 33(2), 333-342 (2022)

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