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Merck
CN

938327

Monobromopyridazinedione-BCN

≥95%

Synonym(s):

((1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl)methyl, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, (2-(2-(2-(3-(4-bromo-2-methyl-3,6-dioxo-3,6-dihydropyridazin-1(2H)-yl)propanamido)ethoxy)ethoxy)ethyl)carbamate, 14-(4-bromo-3,6-dihydro-2-methyl-3,6-dioxo-1(2H)-pyridazinyl)-12-oxo-, 5,8-Dioxa-2,11-diazatetradecanoic acid

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About This Item

Empirical Formula (Hill Notation):
C25H35BrN4O7
CAS Number:
2922766-53-6
Molecular Weight:
583.47
NACRES:
NA.21
Assay:
≥95%
Form:
(Liquid or Paste)

Key Documents

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InChI

1S/C25H35BrN4O7/c1-29-24(33)21(26)16-23(32)30(29)11-8-22(31)27-9-12-35-14-15-36-13-10-28-25(34)37-17-20-18-6-4-2-3-5-7-19(18)20/h16,18-20H,4-15,17H2,1H3,(H,27,31)(H,28,34)/t18-,19+,20-

InChI key

HRXOLPCYGOYYAZ-ACDBMABISA-N

SMILES string

O=C(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])NCCOCCOCCNC(CCN(N3C)C(C=C(Br)C3=O)=O)=O

assay

≥95%

form

(Liquid or Paste)

color

colorless to light yellow

storage temp.

−20°C

Quality Level

100

Application

New reagent for cysteine modification, useful for ADC & Bioconjugation

Other Notes

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000314556
0000314556
0000353666

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Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers
Wall A, et al.
Organic & Biomolecular Chemistry, 17(34), 7870-7873 (2019)
Anders Dinesen et al.
Bioconjugate chemistry, 33(2), 333-342 (2022-02-08)
Albumin-nucleic acid biomolecular drug designs offer modular multifunctionalization and extended circulatory half-life. However, stability issues associated with conventional DNA nucleotides and maleimide bioconjugation chemistries limit the clinical potential. This work aims to improve the stability of this thiol conjugation and

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