939846
NanoFabTx™ phenyl boronate functionalized PAMAM dendrimer
20 ml/ml aqueous solution, for protein delivery
Synonym(s):
Poly(amidoamine)
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About This Item
Linear Formula:
[NH2(CH2)2NH2]:(G=5); dendri PAMAM(NH2)128
UNSPSC Code:
12352200
NACRES:
NA.21
form
liquid
concentration
15-25 mg/mL
color
colorless
density
1.005 g/mL
storage temp.
2-8°C
Quality Level
General description
About this material:
The NanoFabTx™ Phenyl Boronate Functionalized PAMAM Dendrimer is a specialized drug delivery solution developed and tested for efficient protein delivery. This dendrimer exhibits a high binding affinity with a wide range of proteins, thanks to its rich phenylboronic acid (PBA) content. By leveraging the electron-deficient nature of phenyl boronic acid, this dendrimer can effectively coordinate with cationic amine and imidazole groups on proteins, enabling nitrogen-boronate complexations and cationic and ionic interactions. Moreover, the PBA moieties on this NanoFabTx™ dendrimer provide opportunities for self-assembly and effectively address existing barriers in the cytosolic delivery of nucleic acids.
More information including application notes can be found under the "More Documents" tab on this page.
The NanoFabTx™ Phenyl Boronate Functionalized PAMAM Dendrimer is a specialized drug delivery solution developed and tested for efficient protein delivery. This dendrimer exhibits a high binding affinity with a wide range of proteins, thanks to its rich phenylboronic acid (PBA) content. By leveraging the electron-deficient nature of phenyl boronic acid, this dendrimer can effectively coordinate with cationic amine and imidazole groups on proteins, enabling nitrogen-boronate complexations and cationic and ionic interactions. Moreover, the PBA moieties on this NanoFabTx™ dendrimer provide opportunities for self-assembly and effectively address existing barriers in the cytosolic delivery of nucleic acids.
More information including application notes can be found under the "More Documents" tab on this page.
Application
Specifically optimized for intracellular protein delivery, including protein complexes, the NanoFabTx(TM) phenyl boronate functionalized PAMAM dendrimer has applications in:
- Therapuetic nuclelic acid and protein delivery - This dendrimer enables the formation of dendrimer-protein complexes thatcan bypass membrane barriers, enable high uptake by mammalian cells, and aid in cysoloic delivery into the cells
- Molecular and cell detection: The high density of boronic groups can be used fro molecular and cell detections such as sugar and H2O2
Features and Benefits
The NanoFabTx™ drug delivery solutions have been tested to ensure effective therapeutic delivery, and they are accompanied by supported protocols and application notes to guide you on your drug delivery journey. Derived from Sigma-Aldrich Product 536709 (ethylenediamine core, generation 5.0), the NanoFabTx™ phenyl boronate functionalized PAMAM dendrimer offers the following features and benefits:
- A ready-to-use formulation for synthesizing dendrimer-protein complexes
- Detailed, step-by-step protocols for protein delivery, along with application data for in vitro delivery
- A drug delivery solution that enables protein delivery into cells without noticeable toxicity or disruption of metabolism
- Flexibility to optimize the material based on protein size and surface properties, providing adaptability for various applications and research needs.
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class
10 - Combustible liquids
wgk
WGK 2
Regulatory Information
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Lin Liu et al.
Biosensors, 13(8), 785-785 (2023-08-25)
It is of great importance to have sensitive and accurate detection of cis-diol-containing biologically related substances because of their important functions in the research fields of metabolomics, glycomics, and proteomics. Boronic acids can specifically and reversibly interact with 1,2- or
Edidiong Nkiruka Essien et al.
International journal of pharmaceutics, 642, 123150-123150 (2023-06-20)
L-sulforaphane (LSF), a natural product developed from cruciferous vegetables, have shown potent anti-inflammatory effect in cancer as well as arthritis. However, the stable delivery of LSF remains a major challenge. Methotrexate (MTX) is currently the first line treatment for managing
Chongyi Liu et al.
Science advances, 5(6), eaaw8922-eaaw8922 (2019-06-18)
Cytosolic protein delivery is of central importance for the development of protein-based biotechnologies and therapeutics; however, efficient intracellular delivery of native proteins remains a challenge. Here, we reported a boronic acid-rich dendrimer with unprecedented efficiency for cytosolic delivery of native
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