description
(Applications: tissue engineering, 3d bioprinting)
composition
(Xeno-free (animal-origin free))
color
transparent
compatibility
(extrusion-based 3D bioprinting, cell culture)
storage temp.
2-8°C
General description
Rethink your bioinks with TissueFab® About the material:
These TissueFab(R) xeno-free bioinks are animal-origin free, tunable, and require no UV, no temperature/pH curing, or chemical crosslinking. This bioink is modified with the YIGSR peptide to promote cell adhesion and proliferation.
Printing and crosslinking parameters:
*Compatible with extrusion-based printing
*Ready to use at room temperature
* Neutral in pH
* Transparent
* Does not require additional functionalization or crosslinking such as methacrylation or UV curing
The TissueFab(R) xeno-free bioinks represent a versatile family of ready-to-use, xeno-free tunable bioink systems. Distinguished by their unique shear-thinning and rapid recovery mechanical properties, these bioinks can uphold the printed structure without the need for UV or other specialized curing methods, making them exceptionally well-suited for cell encapsulation. Furthermore, the introduction of cell culture media post-printing can provide additional stabilization to the printed structure and promote cell growth.
Similar to RGD, the YIGSR peptide is derived from the extracellular matrix (ECM) protein laminin and is known to promote cell adhesion. This YIGSR peptide modified TissueFab(R) bioink can enhance the interaction between cells and the surrounding biomaterial, supporting cell attachment, spreading and proliferation within 3D printed constructs. This peptide-containing bioink is valuable in tissue engineering and regenerative medicine applications, where the establishment of robust cell-matrix interactions is essential for the development and functional of biofabricated tissues.
More information and a step by step protocol can be found under the "More Documents" section of this page.
These TissueFab(R) xeno-free bioinks are animal-origin free, tunable, and require no UV, no temperature/pH curing, or chemical crosslinking. This bioink is modified with the YIGSR peptide to promote cell adhesion and proliferation.
Printing and crosslinking parameters:
*Compatible with extrusion-based printing
*Ready to use at room temperature
* Neutral in pH
* Transparent
* Does not require additional functionalization or crosslinking such as methacrylation or UV curing
The TissueFab(R) xeno-free bioinks represent a versatile family of ready-to-use, xeno-free tunable bioink systems. Distinguished by their unique shear-thinning and rapid recovery mechanical properties, these bioinks can uphold the printed structure without the need for UV or other specialized curing methods, making them exceptionally well-suited for cell encapsulation. Furthermore, the introduction of cell culture media post-printing can provide additional stabilization to the printed structure and promote cell growth.
Similar to RGD, the YIGSR peptide is derived from the extracellular matrix (ECM) protein laminin and is known to promote cell adhesion. This YIGSR peptide modified TissueFab(R) bioink can enhance the interaction between cells and the surrounding biomaterial, supporting cell attachment, spreading and proliferation within 3D printed constructs. This peptide-containing bioink is valuable in tissue engineering and regenerative medicine applications, where the establishment of robust cell-matrix interactions is essential for the development and functional of biofabricated tissues.
More information and a step by step protocol can be found under the "More Documents" section of this page.
Application
The TissueFab® xeno-free bioinks are versatile materials suitable for a range of bioprinting applications, including 3D cell culture, tissue engineering, and regenerative medicine. Their xeno-free (or animal-free) nature makes them ideal for studying complex cell-matrix or cell-cell interactions, while the UV-free bioprinting process promotes excellent cell compatibility for diverse applications, such as:
*3D Cell Culture: Providing an environment for cultivating and studying cells in a 3D setting, replicating natural tissue conditions and enabling the study of cell behavior and interactions in a controlled environment.
*Tissue Engineering: Supporting the development of biofabricated tissues and organoids for regenerative medicine and therapeutic applications.
*Drug Screening: Facilitating the creation of 3D cell culture models for drug screening and testing in a biologically relevant environment.
*Regenerative Medicine: Providing a platform for the development of biofabricated tissues and constructs for tissue repair and regeneration.
*3D Cell Culture: Providing an environment for cultivating and studying cells in a 3D setting, replicating natural tissue conditions and enabling the study of cell behavior and interactions in a controlled environment.
*Tissue Engineering: Supporting the development of biofabricated tissues and organoids for regenerative medicine and therapeutic applications.
*Drug Screening: Facilitating the creation of 3D cell culture models for drug screening and testing in a biologically relevant environment.
*Regenerative Medicine: Providing a platform for the development of biofabricated tissues and constructs for tissue repair and regeneration.
Features and Benefits
Key Features and Benefits:
The TissueFab® xeno-free bioinks are:
• Xeno-free, animal-origin free
• Tunable
• Ready to use as room temperature
• Facile curable - no UV, temperature/pH curing, or chemical crosslinking required
• Transparent - excellent visibility after printing and cell culture
• YIGSR modified - to promote cell attachment, spreading and proliferation
In addition, each TissueFab® material is developed and tested to meet strict criteria to best suit researchers′ needs. This includes:
• Printability
• Cell viability
• Biocompatibility
• Mechanical and rheological properties
This product contains 3mL of bioink solution.
The TissueFab® xeno-free bioinks are:
• Xeno-free, animal-origin free
• Tunable
• Ready to use as room temperature
• Facile curable - no UV, temperature/pH curing, or chemical crosslinking required
• Transparent - excellent visibility after printing and cell culture
• YIGSR modified - to promote cell attachment, spreading and proliferation
In addition, each TissueFab® material is developed and tested to meet strict criteria to best suit researchers′ needs. This includes:
• Printability
• Cell viability
• Biocompatibility
• Mechanical and rheological properties
This product contains 3mL of bioink solution.
Legal Information
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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First tests of extrusion Process Using Arthroscopic 3D Bioprinting Handheld Tools Prototypes
Gapinski T, et al.
Biomaterials, 158, 60-60 (2020)
MP01-03 Xeno-Free Peptide-Functionalized Bioinks Improve Ex Vico Culture of Human Testicular Tissues
Robinson M, et al.
The Journal of Urology, 4, 209-209 (2023)
Aragaw Gebeyehu et al.
Scientific reports, 11(1), 372-372 (2021-01-13)
A series of stable and ready-to-use bioinks have been developed based on the xeno-free and tunable hydrogel (VitroGel) system. Cell laden scaffold fabrication with optimized polysaccharide-based inks demonstrated that Ink H4 and RGD modified Ink H4-RGD had excellent rheological properties.
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