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Merck
CN

JKA5101

Sigma-Aldrich

HS-PEG7500-COOH

greener alternative

average MN 7,500, COOH, cross-linking reagent polymerization reactions thiol reactive, cross-linking reagent polymerization reactions amine reactive

Synonym(s):

HS-PEG-COOH, Polyethylene glycol, Thiol-PEG-Carboxyl, HS-PEG-COOH

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About This Item

Linear Formula:
HS(CH2CH2O)nCH2COOH
UNSPSC Code:
12162002
NACRES:
NA.23

Key Documents

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Product Name

HS-PEG7500-COOH, average Mn 7,500

form

solid

mol wt

average Mn 7,500

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions
reactivity: amine reactive
reagent type: cross-linking reagent
reaction type: Polymerization Reactions
reactivity: thiol reactive

greener alternative product characteristics

Safer Solvents and Auxiliaries
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greener alternative category

Aligned

polymer architecture

shape: linear
functionality: heterobifunctional

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General description

Product is a thiolated carboxylic-polyethylene . 4α;-sulfanyl—ω carboxy PEG (HS–PEG–COOH) heterobifunctional PEGs with functional end-groups of very different reactivity. HS-PEG-COOH inhibits nonspecific binding to living cells.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Application

Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
HS-PEG-COOH may be tethered to the gold nanoparticle end during the fabrication of epidermal growth factor (EGF)-conjugated surface-enhanced Raman spectroscopy (SERS) nanoparticles. HS-PEG-COOH was coated onto silicon-on-insulator photonic biosensor chips. Quantum dots (QD)/ virus-like particles (VLPs) could be obtained only from HS-PEG-COOH-coated QDs. It may be used to stabilize nanoparticles and prevent its aggregation.

Legal Information

Product of JenKem Technology

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Quantum dot encapsulation in viral capsids."
Dixit SK, et al.
Nano Letters, 6(9), 1993-1999 (2006)
SOI optical microring resonator with poly (ethylene glycol) polymer brush for label-free biosensor applications
De Vos, K, et al.
Biosensors And Bioelectronics, 24(8), 2528-2533 (2009)
Antibody-functionalized SERS tags with improved sensitivity.
Guarrotxena N and Bazan GC
Chemical Communications (Cambridge, England), 47(31), 8784-8786 (2011)
Nam, K., et al.
Biomaterials, 33(32) (2012)
Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles.
Wang X, et al.
Cancer Research, 71(5), 1526-1532 (2011)
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