L021000
DCA Deblock
with Dichloromethane
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About This Item
NACRES:
NA.21
UNSPSC Code:
41116004
Quality Level
product line
Proligo Reagents
form
liquid
storage condition
dry at room temperature
concentration
42.2-51.6 g/L (DCA content, titration)
impurities
≤200 ppm water content (Karl Fischer)
color
clear
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General description
Deblock solution contains dichloroacetic acid (DCA) in dichloromethane that assists in the removal of the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, before the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.
Preparation Note
Dicloromethane / Dichloroacetic acid 97/3 (v/v)
Other Notes
Deblock solution containing dichloroacetic acid (DCA) in dichloromethane removes the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.
signalword
Danger
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
危险化学品
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