P56100
Pyrazinecarboxylic acid
99%
Synonym(s):
Pyrazinoic acid
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About This Item
Empirical Formula (Hill Notation):
C5H4N2O2
CAS Number:
Molecular Weight:
124.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-718-1
Beilstein/REAXYS Number:
112305
MDL number:
Assay:
99%
Form:
powder
InChI
1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
InChI key
NIPZZXUFJPQHNH-UHFFFAOYSA-N
SMILES string
OC(=O)c1cnccn1
assay
99%
form
powder
Quality Level
Related Categories
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mohamed Abdel-Aziz et al.
European journal of medicinal chemistry, 45(8), 3384-3388 (2010-05-22)
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity
Wanliang Shi et al.
Science (New York, N.Y.), 333(6049), 1630-1632 (2011-08-13)
Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the duration of tuberculosis chemotherapy. PZA is hydrolyzed intracellularly to pyrazinoic acid (POA) by pyrazinamidase (PZase, encoded by pncA), an enzyme frequently lost in PZA-resistant strains
Michael Groll et al.
Structure (London, England : 1993), 14(3), 451-456 (2006-03-15)
The dipeptide boronic acid bortezomib, also termed VELCADE, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the treatment of other malignancies is being explored. We determined the crystal structure of the
Takashi Iwanaga et al.
The Journal of pharmacology and experimental therapeutics, 320(1), 211-217 (2006-10-18)
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB), losartan, decreases SUA level, whereas other ARBs, such as candesartan, have no lowering effect. Because
Marta Filipa Simões et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37(3-4), 257-263 (2009-06-06)
Pyrazinamide (PZA) is active against M. tuberculosis and is a first line agent for the treatment of human tuberculosis. PZA is itself a prodrug that requires activation by a pyrazinamidase to form its active metabolite pyrazinoic acid (POA). Since the
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