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Merck
CN

QBD10007

Biotin-dPEG®24-TFP ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C67H117F4N3O28S
Molecular Weight:
1520.71
UNSPSC Code:
12352108
PubChem Substance ID:
329823871
NACRES:
NA.22

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InChI key

DZXHDWHQLGLRLF-UHFFFAOYSA-N

SMILES string

O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O

assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations, reaction type: Biotinylations
reactivity: amine reactive, reagent type: cross-linking reagent

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Related Categories

Features and Benefits

The Biotin-dPEG®24-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyze more slowly than NHS esters in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®24-TFP ester has a long spacer of precise length (99.3 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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