QBD10009
Biotin-dPEG®4-TFP ester
Synonym(s):
Polyethylene glycol
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About This Item
Empirical Formula (Hill Notation):
C27H37F4N3O8S
Molecular Weight:
639.66
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
InChI key
XBGOXOZYGAXNFP-UHFFFAOYSA-N
SMILES string
O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O
assay
>90%
form
solid or viscous liquid
reaction suitability
reaction type: Biotinylations, reaction type: Biotinylations
reactivity: amine reactive, reagent type: cross-linking reagent
polymer architecture
shape: linear
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
Related Categories
Application
Biotin-dPEG®4-TFP ester is an amphiphilic and hydrolytically stable compound used as a cross-linking reagent in biotinylations reactions.
Features and Benefits
Biotin-dPEG®4-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®4-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Bioconjugate techniques
Bioconjugate Techniques (2013)
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