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Merck
CN

QBD10211

m-dPEG®4-NHS ester

Synonym(s):

2,5-Dioxo-1-pyrrolidinyl 4,7,10,13-tetraoxatetradecanoate, Polyethylene glycol, Triethylene glycol methyl ether 2-(succinimidyloxycarbonyl)ethyl ether

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About This Item

Empirical Formula (Hill Notation):
C14H23NO8
CAS Number:
622405-78-1
Molecular Weight:
333.33
NACRES:
NA.22
PubChem Substance ID:
329823894
UNSPSC Code:
12352108
MDL number:
MFCD11041112

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InChI

1S/C14H23NO8/c1-19-6-7-21-10-11-22-9-8-20-5-4-14(18)23-15-12(16)2-3-13(15)17/h2-11H2,1H3

SMILES string

O=C1CCC(N1OC(CCOCCOCCOCCOC)=O)=O

InChI key

MAYFFZZPEREGBQ-UHFFFAOYSA-N

assay

>90%

form

solid or viscous liquid

reaction suitability

reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Related Categories

Features and Benefits

The m-dPEG®4-NHS ester provides a variety of means to modify small molecules, peptides, proteins, and functionalized surfaces (metals, glass, and others). The single molecular weight methoxy-terminated dPEG® molecules are hydrophilic and non-immunogenic of exact length. Modification with m-dPEG® reagents can improve water solubility, increase hydrodynamic volume, eliminate or reduce non-specific binding, protect peptides and proteins from proteolysis, reduce or eliminate immunogenicity, and increase serum half-life in vivo. The m-dPEG®4-NHS (N-hydroxysuccinimide) ester reacts with amines.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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