QBD11471
MAL-dPEG®12-Tris(m-dPEG®24)3
>95% (HPLC)
Synonym(s):
Branched Maleimide-PEG-m, Branched mPEG-maleimide, MAL-NH-PEG600-Tris(mPEG1000)3, MAL-PEG12-Tris(m-PEG24)3
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C194H378N6O94
Molecular Weight:
4299.06
NACRES:
NA.22
UNSPSC Code:
12352106
assay
>95% (HPLC)
form
solid or viscous liquid
reaction suitability
reaction type: Pegylations
polymer architecture
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
Features and Benefits
MAL-dPEG12-Tris(m-dPEG24)3 is a thiol-reactive, methyl-terminated, four-arm monodispersed PEG product designed to modulate biodistribution of conjugates. Tris forms the core of the molecule. Three equal-length methyl-terminated long arms plus one maleimido-terminated short arm extend from the tris core. From the maleimido olefin to the terminal methyl groups on each arm, the end-to-end length of this product is 127 atoms with an average distance of 103.7 Å. The amphiphilic PEG imparts hydrophilicity to conjugates, reduces or eliminates the conjugates′ antigenicity, and increases the hydrodynamic volume of conjugated molecules. Applications for this product include eradicating renal clearance, maintaining in vivo circulation for more extended periods, and suppressing immune responses to conjugates.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Haiming Ding et al.
Bioconjugate chemistry, 24(11), 1945-1954 (2013-11-02)
The tumor-associated glycoprotein-72 (TAG-72) antigen is highly overexpressed in various human adenocarcinomas and anti-TAG-72 monoclonal antibodies, and fragments are therefore useful as pharmaceutical targeting vectors. In this study, we investigated the effects of site-specific PEGylation with MW 2-4 kDa discrete
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service