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Merck
CN

790427C

Avanti

06:0 PC-d22

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C20H18NO8PD22
CAS Number:
328946-18-5
Molecular Weight:
475.64
MDL number:
MFCD00003646
NACRES:
NA.12
UNSPSC Code:
12352211
Assay:
>99% (TLC)
Form:
liquid

Key Documents

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Product Name

06:0 PC-d22, Avanti Research™ - A Croda Brand 790427C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (790427C-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790427C

concentration

10 mg/mL (790427C-10mg)

shipped in

dry ice

storage temp.

−20°C

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General description

Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.
Phosphatidylcholine is a zwitterionic glycerophospholipid, containing choline. It consists of a head and two tails. Head group contains choline and phosphate. Head is polar and water soluble. The tail group contains two fatty acyl chains esterified with glycerol. Tail group is non-polar and water-insoluble. Phosphatidylcholine is synthesized in the liver by phosphatidylethanolamine methyltransferase (PEMT) pathway. It is also synthesized by the Kennedy pathway and the Lands cycle.

Application

06:0 PC-d22 (1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine) has been used:
  • as bicelles for lipid in HN-HN nuclear overhauser enhancement (NOE) detection
  • as an internal standard in residual algal suspension for liquid chromatography-mass spectrometry analysis (LC-MS/MS)
  • to produce bicelles to investigate C-peptide and membrane interaction by diffusion nuclear magnetic resonance (NMR) and 2D total correlation spectroscopy (TOCSY)

Biochem/physiol Actions

Phosphatidylcholine (PC) is a major component of the membrane bilayer. It is involved in the synthesis of signaling molecules. PC is the precursor for the synthesis of sphingomyelin and phosphatidylserine.

Packaging

5 mL Clear Glass Sealed Ampule (790427C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

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Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage
Moessinger C, et al.
BMC Cell Biology, 15(1), 43-43 (2014)
Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions
Ito T, et al.
Metabolomics, 9(1), 178-187 (2013)
pH-dependent interaction between C-peptide and phospholipid bicelles
Unnerstaale S and Maler L
Journal of biophysics (Hindawi Publishing Corporation : Online), 2012(1), 43-43 (2012)
Biochemistry of Lipids, Lipoproteins and Membranes (2015)
The unusual transmembrane partition of the hexameric channel of the hepatitis C virus
Chen W, et al.
Structure, 26(4), 627-634 (2018)
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