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Merck
CN

810209X

Avanti

C6-NBD Ceramide

Avanti Research™ - A Croda Brand

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine:methanol (8:2)

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About This Item

Empirical Formula (Hill Notation):
C30H49N5O6
CAS Number:
94885-02-6
Molecular Weight:
575.74
MDL number:
MFCD02259244
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

C6-NBD Ceramide, Avanti Research™ - A Croda Brand 810209X

SMILES string

[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO

InChI

1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1

InChI key

HZIRBXILQRLFIK-VPZZKNKNSA-N

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810209X-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810209X

concentration

1 mg/mL (810209X-1mg)

shipped in

dry ice

storage temp.

−20°C

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General description

C6-NBD ceramide is a fluorescent labelled compound, known to be useful for the detection of enzymatic action. C6-NBD ceramide is preferred over radioactive compounds.

Application

C6-NBD Ceramide is suitable as a substrate for sphingomyelin synthase activity assay.

Biochem/physiol Actions

Sphingolipid metabolism yields ceramide as one of the products. The family of ceramide synthases catalyses its synthesis. The ceramides differ in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

Packaging

5 mL Amber Glass Screw Cap Vial (810209X-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

target_organs

Central nervous system, Eyes,Central nervous system, Liver,Kidney

Storage Class

3 - Flammable liquids

wgk

WGK 3

Regulatory Information

危险化学品
易制毒化学品（2类）
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Handbook of Glycosyltransferases and Related Genes, 5-5 (2011)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)
A role for ceramides, but not sphingomyelins, as antagonists of insulin signaling and mitochondrial metabolism in C2C12 myotubes
Park M, et al.
The Journal of Biological Chemistry, 291(46), 23978-23988 (2016)

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