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About This Item
Empirical Formula (Hill Notation):
C46H80BF2N4O10P
CAS Number:
Molecular Weight:
928.93
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
TopFluor™ PS, Avanti Research™ - A Croda Brand 810283C
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810283C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810283C
concentration
1 mg/mL (810283C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules.
Application
TopFluor™ PS may be used in liposome generation and as a synthetic fluorescent PS analogue to study PS distribution and dynamics in mouse embryonic fibroblasts (MEFs). It has also been used to study the fluorescence resonance energy transfer (FRET) efficiency between TopFluor PtdSer and RFP-K-RasG12V PBD mutants and to directly measure its interaction with RFP-K-RasG12V PBD mutant.
Biochem/physiol Actions
Phosphoserine (PS) can be used as a template for the recognition of cancer antigen 125 (CA 125). It is very essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans. It plays a key role in memory related issues and several other cognitive activities. PS actively participates in the locomotor functions. TopFluor-PS/1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phospho-l-serine is a synthetic fluorescent PS analog.
Packaging
5 mL Amber Glass Screw Cap Vial (810283C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
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Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output
Zhou Y, et al.
Cell, 168(1), 239-251 (2017)
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
Conrad KS, et al.
Nature Communications, 8(1908), 1-13 (2017)
Phosphatidylserine dynamics in cellular membranes
Kay JG, et al.
Molecular Biology of the Cell, 23(11), 2198-2212 (2012)
Adsorption of O-phospho-L-serine and L-serine onto poorly crystalline apatite
Benaziz L, et al.
Journal of Colloid and Interface Science, 238(1), 48-53 (2001)
Phosphoserine imprinted nanosensor for detection of Cancer Antigen 125
Buyuktiryaki S, et al.
Talanta, 167, 172-180 (2017)
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